Prenatal Sonographic Features of Fraser Syndrome with Multiple Craniofacial Abnormalities: A Case Report

Submit Manuscript | http://medcraveonline.com of this syndrome is estimated below 0.04 per 10.000 live born infants and 1.1 in 10.000 stillbirths [2]. It is mainly characterized by variable expressions of cryptophthalmos, syndactyly, abnormal genitalia, laryngeal malformations and urogenital defects [2-4]. Antenatally diagnosed cases had more manifestations result in a pathological amount of amniotic fluid [3]. Prenatal diagnosis is getting more difficult in the case of inconstant and variable sonographic findings especially when oligohydramnios and a healthy previous sib are presented [2,5]. Oligohydramnios can occur at any time during pregnancy, it is most common during the last trimester but its occurrence in earlier in pregnancy has poorer prognosis with about 80-90% mortality rates. It could result from placental insufficiency or congenital abnormalities in the fetus such as agenesis of the kidneys or atresia of the urethra [6]. Here we described a prenatal case with Fraser syndrome indicated severe oligohydramnios, high airway obstruction, bilateral renal agenesis and multiple associated craniofacial anomalies in a nonconsanguineous couple.